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KMID : 0358420080510080850
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Korean Journal of Obstetrics and Gynecology
2008 Volume.51 No. 8 p.850 ~ p.857
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Epithelial ovarian cancer in patients under 20 years of age
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Choi Ji-Hyang
Park Jong-Sup
Hur Soo-Young
Namkoong Sung-Eun
Lee Jun-Mo
Bae Seog-Nyen
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Abstract
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Objective: Epithelial ovarian cancer is the most common cause of death due to gynecologic malignancies in adults, but is rare in children and adolescents. This is a report of series of such patients under 20 years of age documenting their presentation, histologic type, stage of disease, treatment, and outcome.
Methods: We collected data on 21 patients with epithelial ovarian cancer under 20 years of age between January 1990 and December 2005. Patient records and pathology were reviewed.
Results: Epithelial ovarian cancer under 20 years of age was 2.2% in overall ovarian cancer. Epithelial ovarian cancer was 42.0% among 50 patients under 20 years of age and the most common histologic type was germ cell tumors(54%). The median age at the time of diagnosis was 17.6 years (range, 13-20 years), and the median follow-up was 87 months (range, 4-175 months). There were seventeen (81.0%) mucinous tumors, four (19.0%) serous tumors. About thirty eight percent were low malignant potential or borderline tumors. About Eighty-five percent (18 patients) of tumors were stage I disease and about fourteen percent (3 patients) were stage III disease at the time of diagnosis. Surgical treatment included conservative surgery in 18 patients (85.7%), total abdominal hysterectomy and bilateral salpingooophorectomy in 3 patients (14.3%).
Conclusion: Epithelial ovarian cancers are rare in patients in children and adolescents. The majority of ovarian cancers in this age group are mucinous tumors, stage I at diagnosis and borderline ovarian tumor. Conservative management is feasible to achieve preservation of fertility.
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KEYWORD
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Epithelial ovarian cancer, Children, Adolescence, Conservative management
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